香港大学与乔治亚大学的研究团队在分析英国生物库数据后发现，血液中氨基酸酪氨酸水平升高与男性寿命缩短存在关联1。这项涉及超过270,000名参与者的大规模研究表明，酪氨酸浓度升高可能使男性预期寿命减少近一年1。研究采用观察性分析和孟德尔随机化两种方法进行验证，即使在控制其他因素后，这种负相关仍然成立1。
值得注意的是，这项关联在女性中未见显著影响1。研究团队发现男性的酪氨酸水平普遍高于女性1。研究未直接测试酪氨酸补充剂的具体影响，但提出可能的作用机制包括胰岛素抵抗和应激反应相关神经递质1。此外，另一种相似的氨基酸苯丙氨酸与寿命之间未发现显著关联1。
A large-scale study involving more than 270,000 UK Biobank participants has identified a connection between elevated blood levels of the amino acid tyrosine and reduced life expectancy in men, potentially reducing male lifespan by nearly one year.1 The research, conducted by teams from the University of Hong Kong and the University of Georgia, employed both observational analysis and Mendelian randomization methods to establish this association.1 Notably, no significant relationship between tyrosine levels and lifespan was observed in women.1
The researchers found that men naturally have higher tyrosine levels than women,1 and the negative correlation with longevity persisted even after controlling for other factors.1 However, the study did not directly test the effects of tyrosine supplements themselves, leaving the underlying biological mechanism unclear.1 Possible explanations for the association include insulin resistance and stress response neurotransmitters.1 In contrast, phenylalanine, another amino acid, showed no significant correlation with lifespan.1
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