麻省理工学院研究人员成功将细菌改造为晶体管，开发出能够执行计算并传输化学信号的生物电路系统1。研究团队利用泛菌创建了两种细菌晶体管和三种中继菌株，这五种菌株可组合构成各类电路1。晶体管对分子OC 6和OC 12产生响应，并生成输出分子OHC 141。为验证该系统的可行性，研究人员搭建了包含24个相互连接的细菌菌落的演示电路，用于对两个输入进行相加运算，每次计算耗时约8小时1。
该研究由麻省理工学院生物工程系负责人Christopher Voigt指导，论文第一作者为博士后Hamid Doosthosseini，Haorong Chen也参与其中1。研究成果已于2026年9月4日发表在《Nature Chemical Biology》杂志上1。研究获得美国国防高级研究计划局(DARPA)和美国情报高级研究计划局(IARPA)的部分资助1。
这一技术前景广阔，研究团队计划将这些生物计算机应用于植物叶片或根部，使植物能够检测和应对干旱、虫害等环境压力1。
Researchers at MIT have engineered bacteria to function as transistors, creating biological circuits capable of performing computations and transmitting chemical signals 1. The team, led by Christopher Voigt, director of MIT's Department of Biological Engineering, developed two types of bacterial transistors and three relay bacterial strains that can be combined to construct various circuit configurations 1.
The study, published in Nature Chemical Biology on September 4, 2026, utilized the bacterium Pantoea agglomerans to create the functional components 1. These bacterial transistors respond to molecular inputs OC6 and OC12, producing an output molecule OHC14 1. The researchers demonstrated the technology by constructing a circuit containing 24 interconnected bacterial colonies that performs addition of two inputs, with each computation requiring approximately eight hours 1. The research was supported in part by the U.S. Defense Advanced Research Projects Agency (DARPA) and the Intelligence Advanced Research Projects Agency (IARPA) 1.
These biological computing systems could be deployed in plant leaves or roots to enable plants to detect and respond to environmental stressors such as drought and pest infestations 1. The work was led by postdoctoral researcher Hamid Doosthosseini and co-authored by Haorong Chen 1.
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