美国医疗团队通过将经过基因编辑的猪肾移植到66岁患者蒂姆·安德鲁斯体内，创造了异种器官移植的新纪录。1这颗来自名叫威尔玛的猪、经过69处基因编辑的肾脏，使患者存活了271天且无需透析，1打破了此前不超过两个月的猪肾异种移植存活纪录。1
安德鲁斯患有因2型糖尿病引发的终末期肾病，在五年内获得人类捐献肾脏的概率仅为9%。1基因编辑猪肾在这一案例中首次成功充当了桥梁器官，使患者能够等待人类永久移植的机会。1约六个月后，猪肾因血管损伤导致器官衰竭，1随即患者接受了人类捐献肾脏的移植。1
在后续的六个月内，患者接受的人类捐献肾脏运作良好，1且未检测到新的人类组织抗体。1研究团队同样未发现任何猪病毒或猪病原体的存在。1这项研究成果已发表在《柳叶刀》医学期刊上。1
A 66-year-old patient with end-stage kidney disease has survived for a record nine months on a genetically modified pig kidney without requiring dialysis, marking a historic milestone in xenotransplantation.1 Tim Andrews, who developed terminal kidney failure due to type 2 diabetes with only a 9% chance of receiving a human kidney transplant within five years, received the engineered organ from a pig named Wilma that underwent 69 genetic modifications.1 The pig kidney functioned for 271 days before vascular damage led to organ failure.1 Subsequently, Andrews underwent successful transplantation with a human donor kidney, which remained healthy six months after the procedure without generating new human tissue antibodies.1
This case represents the first instance of a genetically modified pig kidney serving as a temporary bridge organ leading to permanent human transplantation.1 Previous attempts at pig kidney xenotransplantation had achieved survival periods of no more than two months, and a separate case in 2024 ended after 52 days when the recipient died from cardiac complications.1 No pig viruses or pig pathogens were detected during or after the procedure.1 The research has been published in The Lancet medical journal.1
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