22岁女孩心脏"破洞"被成功修补

22岁患者阿琪因先天性心脏病室间隔缺损合并重度肺动脉高压，曾一度失去手术治疗机会1。其肺动脉收缩压初期高达109mmHg，远超15—30mmHg的正常参考值1。北京大学深圳医院心血管外科团队采用半年规范的靶向药物治疗，成功将其肺动脉收缩压降至29mmHg1，使患者重新具备了接受手术的条件。

手术治疗面临极大挑战，因缺损位置紧邻主动脉瓣膜，且邻近右冠状动脉的解剖位置异常，容错空间极小1。医疗团队最终采用微创介入封堵术进行修补，全程用时不到一小时1，成功完成缺损封堵，使患者重获健康。

A 22-year-old patient named Aqi suffered from a congenital ventricular septal defect combined with severe pulmonary arterial hypertension, which initially left her without viable surgical options 1. The condition caused significant chest tightness and dyspnea even with minimal physical activity, stemming from an abnormal "hole" in her heart 1.

The cardiovascular surgery team at Peking University Shenzhen Hospital devised a two-stage treatment approach to address her condition 1. Initially, Aqi's pulmonary artery systolic pressure measured 109 mmHg, far exceeding the normal range of 15–30 mmHg 1. After six months of standardized targeted pharmacological therapy, her pulmonary artery systolic pressure decreased to 29 mmHg, bringing it within normal limits 1.

Following successful medical stabilization, the surgical team performed a minimally invasive catheter-based closure procedure to seal the heart defect, completing the intervention in less than an hour 1. The operation presented significant technical challenges due to the defect's proximity to the aortic valve and the anatomically abnormal location of the right coronary artery, leaving minimal margin for error 1.