一名6岁女童在2025年3月于上海交通大学医学院附属新华医院接受基因编辑治疗后死亡,上海交通大学医学院26日宣布对此事进行全面调查1。该女童患有CHD3基因突变导致的Snijders Blok–Campeau综合症1,接受治疗后出现发热、肾脏损伤等症状,并在一周内死亡1。医院内部评估认为死因为血栓性微血管病1。
这一死亡事件此前未被公开披露1。相关的研究论文随后删除了对女童家庭的致谢1。该女童的父母为治疗投入了约86万美元的费用1。
A six-year-old girl died within one week after undergoing gene-editing therapy at Shanghai Jiao Tong University School of Medicine's affiliated Xinhua Hospital in March 2025 1. The child, born in 2019, had been diagnosed with Snijders Blok–Campeau syndrome caused by a CHD3 gene mutation 1. Following treatment, she developed fever and kidney damage 1, with the hospital's internal assessment concluding that thrombotic microangiopathy was the cause of death 1.
Shanghai Jiao Tong University School of Medicine announced on the 26th that it would conduct a comprehensive investigation into the incident 1. The death had not been previously disclosed to the public 1, and a related research paper subsequently removed acknowledgments referencing the girl's family 1. The parents had invested approximately 860,000 US dollars in the treatment 1.
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