一名6岁女童在2025年3月于上海交通大学医学院附属新华医院接受基因编辑治疗后死亡，上海交通大学医学院26日宣布对此事进行全面调查[1]。该女童患有CHD3基因突变导致的Snijders Blok–Campeau综合症[1]，接受治疗后出现发热、肾脏损伤等症状，并在一周内死亡[1]。医院内部评估认为死因为血栓性微血管病[1]。
这一死亡事件此前未被公开披露[1]。相关的研究论文随后删除了对女童家庭的致谢[1]。该女童的父母为治疗投入了约86万美元的费用[1]。
A six-year-old girl died within one week after undergoing gene-editing therapy at Shanghai Jiao Tong University School of Medicine's affiliated Xinhua Hospital in March 2025 [1]. The child, born in 2019, had been diagnosed with Snijders Blok–Campeau syndrome caused by a CHD3 gene mutation [1]. Following treatment, she developed fever and kidney damage [1], with the hospital's internal assessment concluding that thrombotic microangiopathy was the cause of death [1].
Shanghai Jiao Tong University School of Medicine announced on the 26th that it would conduct a comprehensive investigation into the incident [1]. The death had not been previously disclosed to the public [1], and a related research paper subsequently removed acknowledgments referencing the girl's family [1]. The parents had invested approximately 860,000 US dollars in the treatment [1].