伦敦城市大学圣乔治分校研究团队近日发表研究成果，提出一种基于进化论原理的癌症治疗新策略[1]。该策略建议在肿瘤仍处于缩小阶段时主动切换化疗方案，而不是等待肿瘤复发后才改变治疗方式，以此阻止癌细胞进化适应[1]。数学模型研究表明，精心安排的多疗法快速切换可以有效防止肿瘤产生耐药性[1]。
研究由该校数学系高级讲师Robert Noble博士领导，成果已发表在《遗传学》期刊2026年第232卷第2期[1]。模型预测显示，两种治疗方案的切换可能仅在相对较小的肿瘤中取得成功，而三种或更多疗法的序列切换则可能消除更大规模的肿瘤[1]。该研究团队还包括来自印度科学教育研究所的学生Srishti Patil、约翰霍普金斯大学本科生Armaan Ahmed，以及巴黎第一大学的Yannick Viossat博士[1]。
目前已有三项临床试验正在进行中，分别针对软组织癌、前列腺癌和乳腺癌展开[1]。
Researchers at St. George's, University of London have developed a novel approach to cancer treatment that applies evolutionary principles to prevent tumors from developing drug resistance.[1] The strategy centers on switching between chemotherapy regimens while tumors are still shrinking, rather than waiting for cancer to recur before changing treatment protocols.[1]
A mathematical model developed by the research team, led by Dr. Robert Noble, a senior lecturer in the mathematics department at St. George's, suggests that carefully timed rapid switches between multiple therapies can block cancer cells from evolving adaptive resistance.[1] The research, published in Genetics volume 232, issue 2 in July 2026, indicates that two-drug treatment combinations may succeed only against relatively small tumors, while three or more sequential therapy switches could potentially eliminate larger cancers.[1] Three clinical trials are currently underway testing the approach in soft tissue cancer, prostate cancer, and breast cancer patients.[1]
The interdisciplinary team behind the findings includes Srishti Patil, a student at the Indian Institute of Science Education and Research, Armaan Ahmed, an undergraduate at Johns Hopkins University, and Dr. Yannick Viossat from Paris Cité University.[1]