中科院合肥物质科学研究院研究团队发现，磁性细菌Magnetospirillum magneticum AMB-1能够显著延长线虫的寿命。1该研究表明，接受磁性细菌处理的线虫平均寿命增加了43.39%，同时其神经和肠道健康也得到保护。1
研究人员揭示了这一延寿效应的核心机制。1研究发现，效应主要通过抑制与铁积累和氧化应激相关的铁死亡来实现。1其中，磁体产生能力对延寿效应至关重要：野生型AMB-1表现出显著的延寿效果，而不产生磁体的NM-AMB-1则无法实现延寿效应。1涉及的关键基因包括ftn-1、bli-3和ads-1。1这项研究成果已发表在《自由基生物学与医学》期刊上，为微生物抗衰老干预策略和老年医学应用提供了新的思路。1
Researchers at the Chinese Academy of Sciences' Hefei Institute of Physical Science have discovered that magnetic bacteria can significantly extend the lifespan of worms while protecting their neurological and intestinal health.1 When exposed to Magnetospirillum magneticum AMB-1, the nematodes experienced an average lifespan increase of 43.39%.1 The research team, led by Professor An Xu, identified that this longevity effect operates primarily through the suppression of ferroptosis, a form of cell death linked to iron accumulation and oxidative stress.1
The study revealed that the bacteria's ability to produce magnetosomes—structures that generate magnetism—proved crucial to the life-extension benefit.1 Wild-type AMB-1 bacteria delivered significant results, whereas a non-magnetosome-producing variant, NM-AMB-1, produced no lifespan extension.1 The mechanism involves the regulation of specific genes, including ftn-1, bli-3, and ads-1.1 These findings were published in Free Radical Biology and Medicine in June 2026 and offer new avenues for microbial anti-aging interventions and geriatric medical applications.1
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