西奈山医学院的研究首次发现，产前和早期生活中接触PFAS（所谓"永久性化学物质"）可能与儿童肠道炎症水平升高相关联 [1]。研究人员追踪了母子配对长达11年 [1]，探索这些难以降解的化学物质在儿童关键发育阶段对肠道发展的潜在影响 [1]。
肠道炎症可能增加患溃疡性结肠炎、克罗恩病和结肠癌等炎症性肠病的风险 [1]。这项研究是同类研究中的首个，针对PFAS对儿童发育阶段的具体影响进行了深入调查 [1]。PFAS此前已被证实与成人炎症性肠病和肠道炎症相关 [1]。
Researchers at Mount Sinai School of Medicine have identified a connection between early exposure to per- and polyfluoroalkyl substances (PFAS) and elevated levels of gut inflammation in children [1]. In what researchers describe as the first study of its kind, scientists tracked mother-child pairs over an 11-year period to examine how prenatal and early-life exposure to these persistent chemicals may affect intestinal development during critical growth stages [1].
The findings suggest that PFAS exposure during formative years could increase the risk of inflammatory bowel diseases, including ulcerative colitis, Crohn's disease, and colorectal cancer [1]. While previous research has established links between PFAS and inflammatory bowel disease and gut inflammation in adults, this study represents the first to investigate the impact on children's developmental trajectories [1].